J Korean Neurosurg Soc.
2010 May;47(5):325-331. 10.3340/jkns.2010.47.5.325.
Little Response of Cerebral Metastasis from Hepatocellular Carcinoma to Any Treatments
- Affiliations
-
- 1Department of Neurosurgery, Seoul National University Bundang Hospital, Seongnam, Korea.
- 2Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.
- 3Department of Neurosurgery, Jeju University Hospital, Jeju, Korea.
- 4Department of Neurosurgery, Seoul National University Boramae Hospital, Seoul, Korea. yschung@snu.ac.kr
- 5Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
- KMID: 2066769
- DOI: http://doi.org/10.3340/jkns.2010.47.5.325
Abstract
OBJECTIVE
We retrospectively evaluated the survival outcome of patients with brain metastasis from hepatocellular carcinoma (HCC).
METHODS
Between 1991 and 2007, a total of 20 patients were diagnosed as having brain metastasis from HCC. The mean age of the patients was 55 +/- 13 years, and 17 (85.0%) were men. Seventeen (85.0%) patients had already extracranial metastases. The median time from diagnosis of HCC to brain metastasis was 18.5 months. Fourteen (70.0%) patients had stroke-like presentation due to intracerebral hemorrhage (ICH). Ten (50.0%) patients had single or solitary brain metastasis. Among a total of 34 brain lesions, 31 (91.2%) lesions had the hemorrhagic components.
RESULTS
The median survival time was 8 weeks (95% CI, 5.08-10.92), and the actuarial survival rates were 85.0%, 45.0%, 22.5%, and 8.4% at 4, 12, 24, and 54 weeks. Age < 60 years, treatment of the primary and/or extracranial lesions, and recurrent ICH were the possible prognostic factors (p = 0.044, p < 0.001, and p = 0.111, respectively). The median progression-free survival (PFS) time was 3 months (95% CI, 0.95-5.05).
CONCLUSION
The overall survival of the patients with brain metastasis from HCC was very poor with median survival time being only 8 weeks. However, the younger patients less than 60 years and/or no extracranial metastases seem to be a positive prognostic factor.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Long Term Survival in Patient with Hepatocellular Carcinoma after Surgical Resection of Brain Metastasis: A Case Report
- Complete Response of Single Nodular Large Hepatocellular Carcinoma with Pulmonary Metastasis by Sequential Transarterial Chemoembolization and Sorafenib: A Case Report
- Hemorrhagic Cerebral Metastases from Hepatocellular Carcinoma: Presumptive Role of Minor Head Trauma
- Unusual Semimembranosus Muscle Metastasis from Hepatocellular Carcinoma
- Uptake of 99mTc - DISDA in Primary Hepatocellular Carcinoma and Metastatic Nodule in the Lung
