J Korean Neurol Assoc.  1997 Jun;15(3):542-554.

The expression of the immediate early genes, c-fos, krox-24 and the late response gene, BKNF induced by antiepileptic drugs

• Suh SC
• Park YC
• Kim SK

Abstract

The expression of the c-fos and krox-24 (immediate early genes: IEGs) and the BDNF (late response gene) were investigated by convulsants such as kainate (KA, 200 micrometer), N-methyl-D-aspartate (NMDA, 10 mM), glutamate (GLU, 2 mM), and picrotoxin (PTX, 20 micrometer in the rat C6 glioma cells. In addition, the changes of their expression patterns were investigated by the anticonvulsants such as a NMDA antagonist MK-801, phenytoin, phenobarbiw, diazepam, and newer antiepileptic drugs like felbamate and gabapentin. NMDA induced c-fos and krox-24 expromiom were decreased spatially by the anticonvulsants. KA, NMDA, GLU, and PTX-induced BDNF expression were increased by the anticonvulsants. These results imply the molecular basis of the anticonvulsant action mechanism lies in differential and coordinated transcriptional regulation of IEGs.

MeSH Terms

Animals
Anticonvulsants*
Brain-Derived Neurotrophic Factor
Convulsants
Diazepam
Dizocilpine Maleate
Genes, Immediate-Early*
Glioma
Glutamic Acid
Kainic Acid
N-Methylaspartate
Phenytoin
Picrotoxin
Rats
Anticonvulsants
Brain-Derived Neurotrophic Factor
Convulsants
Diazepam
Dizocilpine Maleate
Glutamic Acid
Kainic Acid
N-Methylaspartate
Phenytoin
Picrotoxin