J Korean Med Assoc.  2008 Oct;51(10):942-948. 10.5124/jkma.2008.51.10.942.

Drug Treatment of Herpes Simplex Infection

• Lee ES

• KMID: 2065034
• DOI: http://doi.org/10.5124/jkma.2008.51.10.942

Abstract

Herpes simplex virus (HSV) is one of Herpesviridae family viruses which belong to DNA viruses. HSV-associated diseases are among the most widespread infections, affecting nearly 60% to 95% of human adults. Labial herpes typically results from infection with HSV type 1 (HSV-1), whereas most genital herpes is caused by HSV type 2 (HSV-2). They are incurable and persist during the lifetime of the host, often in latent form. Antiviral agents do not cure HSV infections, but rather modify the clinical course of the disease. Topical, oral, or intravenous antiviral agents may be used in the management of HSV infections. Acyclovir, valacyclovir hydrochloride, and famciclovir are the 3 antiviral drugs commonly used to treat symptomatic HSV infections. However, it is very difficult to choose an appropriate drug and dosing regimen.

Keyword

Herpes simplex virus; Antiviral agents; Therapy

MeSH Terms

2-Aminopurine
Acyclovir
Adult
Antiviral Agents
DNA Viruses
Herpes Genitalis
Herpes Simplex
Herpesviridae
Humans
Methylmethacrylates
Polystyrenes
Simplexvirus
Valine
2-Aminopurine
Acyclovir
Antiviral Agents
Methylmethacrylates
Polystyrenes
Valine