J Korean Diabetes Assoc.  1999 Dec;23(6):857-862.

A Case of Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Associated with Amitriptyline in a Patient with Diabetic Neuropathy

• Lee YS
• Yoo SD
• Lee YH

Abstract

Amitriptyline is an effective drug for diabetic neuropathy, but rarely cause syndrome of inappropriate antidiuretic hormone (SIADH) secondary to amitriptyline administration. We experienced a case of SIADH associated with amitriptyline in a patient with diabetic neuropathy. A 64-year-old diabetic women was admitted to the hospital because of severe general weakness and obtunded mentality. Medical history shows that she was treated with amitriptyline for peripheral painful diabetic neuropathy in the past 5 years. Her conditions were including severe hyponatremia, decreased serum osmolality, and elevated urine sodium concentrations, which is consistent with SIADH. With discontinuation of amitriptyline, fluid restriction and hypertonic saline administration, serum sodium level was normalized and general conditions improved. We experienced SIADH that was associated with amitriptyline treatment for diabetic neuropathy, thus the current report is to bring an awareness of hyponatremia in our medical community.

Keyword

SIADH; Amitriptyline; Diabetic neuro-pathy

MeSH Terms

Amitriptyline*
Diabetic Neuropathies*
Female
Humans
Hyponatremia
Inappropriate ADH Syndrome
Middle Aged
Osmolar Concentration
Sodium
Amitriptyline
Sodium