J Korean Diabetes.  2011 Dec;12(4):190-193. 10.4093/jkd.2011.12.4.190.

Use of Oral Hypoglycemic Agents in Type 2 Diabetic Patients with Hepatic Dysfunction

• Lee KY

• KMID: 2059849
• DOI: http://doi.org/10.4093/jkd.2011.12.4.190

Abstract

The prevalence of type 2 diabetes mellitus in the Korea has increased dramatically over the past decade. Clinicians can prescribe the following six currently available classes of oral hypoglycemic agents: sulfonylureas, meglitinides, biguanides, thiazolidinediones, alpha-glucosidase inhibitors and dipeptidyl peptidase inhibitors. The availability of various oral hypoglycemic agents has given rise to several adverse effects and may result in worse outcomes in patients with comorbid conditions such as liver dysfunction, renal impairment and heart failure. When taking a cross-sectional view of hepatic dysfunction, we find that hepatitis B and alcoholic liver disease are most prevalent in Korea. The use of oral hypoglycemic agents in type 2 diabetic patients with hepatic dysfunction requires many considerations.

Keyword

Type 2 diabetes mellitus; Liver diseases; Hypoglycemic agents; Oral administration

MeSH Terms

Administration, Oral
alpha-Glucosidases
Biguanides
Diabetes Mellitus, Type 2
Heart Failure
Hepatitis B
Humans
Hypoglycemic Agents
Korea
Liver Diseases
Liver Diseases, Alcoholic
Prevalence
Protease Inhibitors
Thiazolidinediones
Biguanides
Hypoglycemic Agents
Protease Inhibitors
Thiazolidinediones
alpha-Glucosidases

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