J Korean Assoc Oral Maxillofac Surg.  2003 Feb;29(1):1-4.

Differentiation of adult canine bone marrow stem cells into neurons

Affiliations
  • 1Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University, Korea. choibh@wonju.yonsei.ac.kr
  • 2Department of Dentistry, Kangnung Asan Hospital, Korea.
  • 3Department of Otolaryngology, Wonju College of Medicine, Yonsei University, Korea.
  • 4Me-Plus dental clinic, Korea.
  • 5Korean Baylor Academy and KIDA, Korea.

Abstract

In this study, we showed that neurons could be generated from adult canine bone marrow stem cells by culturing with DMSO/BHA/FeCl2. These neurons differentiated from the bone marrow stem cells formed neurites, expressed neuron-specific markers. This differentiation was enhanced by FeCl2. These results suggest that iron can effectively initiate differentiation of adult bone marrow stem cells into neurons.

Keyword

Neuronal differentiation; Tissue engineering; Cell culture; Stem cells

MeSH Terms

Adult*
Bone Marrow*
Cell Culture Techniques
Humans
Iron
Neurites
Neurons*
Stem Cells*
Tissue Engineering
Iron
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