J Cerebrovasc Endovasc Neurosurg.  2014 Mar;16(1):5-10. 10.7461/jcen.2014.16.1.5.

Frameless Stereotactic Aspiration for Spontaneous Intracerebral Hemorrhage and Subsequent Fibrinolysis Using Urokinase

• Chang YH
• Hwang SK

• KMID: 2055278
• DOI: http://doi.org/10.7461/jcen.2014.16.1.5

Abstract

OBJECTIVES
The optimal management of patients with spontaneous intracerebral hemorrhage (ICH) remains controversial. The aim of this study was to evaluate technical results and clinical outcomes of frameless stereotactic aspiration and fibrinolysis using urokinase performed in a single center.
MATERIALS AND METHODS
The subjects of this study were 62 consecutive patients with spontaneous ICH who were treated with frameless stereotactic aspiration and subsequent fibrinolysis using urokinase between February 2009 and June 2010 in our hospital. The surgical results, procedure-related complications, and clinical outcomes were evaluated.
RESULTS
A total of 62 patients were enrolled in the study. The median age was 54 years (range, 32-86). The mean initial Glasgow coma scale score was 7.7 (range 5-11). The mean initial hemorrhage volume was 43 cm3 (range 30-70). Seven patients (11.2%) died of respiratory failure (four patients), postoperative edema (two patients), and heart disease (one patient). There were seven cases of procedure-related complications (11.2%), including malpositioning of catheters (two patients), pneumocephalus (one patient), and rebleeding (four patients, 6.4%). At the three-month follow-up, a good outcome (three-month Glasgow outcome scale > 3) was noted in 32 patients (51.6%).
CONCLUSIONS
Frameless stereotactic aspiration and subsequent fibrinolytic thearpy using urokinase for spontaneous ICH is a simple and safe procedure with low mortality and rebleeding rate.

Keyword

Intracerebral hemorrhage; Frameless; Stereotactic aspiration; Fibrinolysis

MeSH Terms

Catheters
Cerebral Hemorrhage*
Edema
Fibrinolysis*
Follow-Up Studies
Glasgow Coma Scale
Glasgow Outcome Scale
Heart Diseases
Hemorrhage
Humans
Mortality
Pneumocephalus
Respiratory Insufficiency
Urokinase-Type Plasminogen Activator*
Urokinase-Type Plasminogen Activator

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