J Biomed Res.
2013 Sep;14(3):177-179.
Case of Sporadic T-cell Lymphosarcoma in Cattle
- Affiliations
-
- 1Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea. jeongks@knu.ac.kr
- 2Stem Cell Therapeutic Research Institute, Kyungpook National University, Daegu 702-701, Korea.
Abstract
- We would like to report a case of bovine lymphosarcoma. Parous cattle from a livestock farmhouse were examined for mutinodular masses in the abdominal cavity after slaughter. For clinical signs, animals presented mild leukemic signs but did not have viral or bacterial infection. Grossly, whitish to yellowish smooth masses similar to fat tissue were covered with a thin membrane. A multilobulated mass formed around the arteri, and there was a large quantity of reddish fluid on the cut surface. Histopathologically, a monomorphic population of lymphocytes was observed along with small amounts of cytoplasm, round nuclei with coarsely granular chromatin, and numerous mitotic figures in the samples. In the tumor lesion, uniformly round cells had invaded with abundant neovascularization. Especially, the immunohistochemical phenotype of tumor cells was positive for anti-CD3 and negative for anti-CD8 and anti-CD20. Therefore, morphological analysis diagnosed the mass as a multinodular bovine lymphosarcoma of T-cell origin without any sign of infection by a viral agent.
