Exp Neurobiol.
2015 Mar;24(1):71-83. 10.5607/en.2015.24.1.71.
Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency
- Affiliations
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- 1Department of East-West Medical Science, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 446-701, Korea.
- 2Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 446-701, Korea.
- 3Department of East-West Medicine, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 446-701, Korea. jihopark@khu.ac.kr
- 4College of Pharmacy, Gachon University, Incheon 406-799, Korea.
- 5Department of Oriental Medicinal Materials and Processing, College of Life Science, Kyung Hee University, Yongin 446-701, Korea.
- 6Research Institute of Medical Nutrition, Kyung Hee University, Yongin 446-701, Korea.
- KMID: 2052853
- DOI: http://doi.org/10.5607/en.2015.24.1.71
Abstract
- Artemisia princeps (AP) is a flowering perennial used as a traditional medicine and dietary supplement across East Asia. No study has yet assessed its effects on synaptic plasticity in hippocampus and much less in a model of ovarian hormone deficiency. We examined the influence of chronic oral AP ethanol extract treatment in ovariectomized rats on the induction of long-term depression in a representative synapse (CA3-CA1) of the hippocampus. Ovariectomized rats demonstrated lower trabecular mean bone mineral densities than sham, validating the establishment of pathology. Against this background of pathology, AP-treated ovariectomized rats exhibited attenuated long-term depression (LTD) in CA1 relative to water-treated controls as measured by increased field excitatory post-synaptic potentials (fEPSP) activation averages over the post-stimulation period. While pathological significance of long-term depression (LTD) in ovariectomized rats is conflicting, that AP treatment significantly affected its induction offers justification for further study of its influences on plasticity and its related disorders.
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