Nucl Med Mol Imaging.  2015 Sep;49(3):231-236. 10.1007/s13139-015-0328-2.

Ga68-DOTA Peptide PET/CT to Detect Occult Mesenchymal Tumor-Inducing Osteomalacia: A Case Series of Three Patients

  • 1Department of Diagnostic Radiology, Singapore General Hospital, 4 Outram Road, Singapore 169608, Singapore.


Tumor-induced osteomalacia (TIO) is a rare disease that manifests with paraneoplasic syndrome and overproduction of fibroblast growth factor 23 (FGF23), leading to renal phosphate wasting and hyperphosphaturia, eventually leading to acquired hypophosphatemic osteomalacia. Diagnosis of this disease is often challenging because of the small size of the lesion, which can be localized in bone or soft tissue anywhere in the body. Detecting these occult mesenchymal tumors (OMT) is of great importance as they are potentially curable after tumor resection. The purpose of this case series is to provide some insight into the diagnosis and localization of OMTassociated with osteomalacia, particularly using functional imaging with Ga68-DOTA peptide PET/CT scans.


Ga68-DOTA peptide orDOTANOC PET/CT; Fibroblast growth factor 23; Occult mesenchymal tumor; Tumor-induced osteomalacia
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