Radiat Oncol J.  2013 Dec;31(4):177-184. 10.3857/roj.2013.31.4.177.

Patterns of care and treatment outcomes for primary thyroid lymphoma: a single institution study

Affiliations
  • 1Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea. jjhmd@yuhs.ac
  • 2Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Abstract

PURPOSE
The aim of this study was to analyze the patterns of care and treatment outcomes in patients with primary thyroid lymphoma (PTL) in a single institution.
MATERIALS AND METHODS
Medical records of 29 patients with PTL treated between April 1994 and February 2012 were retrospectively reviewed. Diagnosis was confirmed by biopsy (n = 17) or thyroidectomy (n = 12). Treatment modality and outcome were analyzed according to lymphoma grade.
RESULTS
The median follow-up was 43.2 months (range, 3.8 to 220.8 months). The median age at diagnosis was 57 years (range, 21 to 83 years) and 24 (82.8%) patients were female. Twenty-five (86.2%) patients had PTL with stage IEA and IIEA. There were 8 (27.6%) patients with mucosa-associated lymphoid tissue (MALT) lymphoma and the remaining patients had high-grade lymphoma. Patients were treated with surgery (n = 2), chemotherapy (n = 7), radiotherapy (n = 3) alone, or a combination of these methods (n = 17). Treatment modalities evolved over time and a combination of modalities was preferred, especially for the treatment of high-grade lymphoma in recent years. There was no death or relapse among MALT lymphoma patients. Among high-grade lymphoma patients, 5-year overall survival (OS) and 5-year progression-free survival (PFS) were 75.6% and 73.9%, respectively. Complete remission after initial treatment was the only significant prognostic factor for OS (p = 0.037) and PFS (p = 0.003).
CONCLUSION
Patients with PTL showed a favorable outcome, especially with MALT lymphoma. Radiotherapy alone for MALT lymphoma and chemotherapy followed by radiotherapy for high-grade lymphoma can be effective treatment options for PTL.

Keyword

Thyroid neoplasms; Non-Hodgkin lymphoma; Physician's practice pattern; Treatment outcome

MeSH Terms

Biopsy
Diagnosis
Disease-Free Survival
Drug Therapy
Female
Follow-Up Studies
Humans
Lymphoid Tissue
Lymphoma*
Lymphoma, B-Cell, Marginal Zone
Lymphoma, Non-Hodgkin
Medical Records
Methods
Physician's Practice Patterns
Radiotherapy
Recurrence
Retrospective Studies
Thyroid Gland*
Thyroid Neoplasms
Thyroidectomy
Treatment Outcome
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