Chonnam Med J.  2012 Dec;48(3):141-149. 10.4068/cmj.2012.48.3.141.

Coronary Stent Thrombosis: Current Insights into New Drug-Eluting Stent Designs

• Kim HK
• Jeong MH

• KMID: 2048802
• DOI: http://doi.org/10.4068/cmj.2012.48.3.141

Abstract

The advances of interventional cardiology have been achieved by new device development, finding appropriate drug regimes, and understanding of pathomechanism. Drug-eluting stents (DES) implantation with dual anti-platelet therapy reduced revascularization without increasing mortality or myocardial infarction compared with bare-metal stenting. However, late-term stent thrombosis (ST) and restenosis limited its value and raised the safety concern. Main mechanisms of this phenomenon are impaired endothelialization and hypersensitivity reaction with polymer. The second generation DES further improved safety and/or efficacy by using thinner stent strut and biocompatible polymer. Recently, new concept DES with biodegradable polymer, polymer-free and bioabsorbable scaffold are under investigation in the quest to minimize the risk of ST.

Keyword

Drug-eluting stents; Coronary thrombosis; Blood platelets

MeSH Terms

Blood Platelets
Cardiology
Coronary Thrombosis
Drug-Eluting Stents
Hypersensitivity
Myocardial Infarction
Polymers
Stents
Thrombosis
Polymers

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