Anat Cell Biol.  2012 Sep;45(3):170-177. 10.5115/acb.2012.45.3.170.

Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats

Affiliations
  • 1Department of Anatomy and Cell Biology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. m.taramoshlou@sbmu.ac.ir
  • 2English Language Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • 3Department of Pathology, AJA University of Medical Sciences, Tehran, Iran.
  • 4Department of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • 5Department of Anatomy and Cell Biology, Gilan University of Medical Sciences, Rasht, Iran.

Abstract

Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science. The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats. In a randomized controlled trial, thirty-six Wistar male rats, 250 to 300 g, received surgical incisions followed by topical application of Aloe vera gel, thyroid hormone cream and silver sulfadiazine 1%. To assess the efficacy of each treatment technique, a histological approach was used to evaluate the mean number of fibroblasts, macrophages, neutrophils, blood vessel sections and thickness of the regenerating epithelium and dermis on days 4, 7 and 14. Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P< or =0.05). Topical administration of Aloe vera gel is recommended as the treatment of choice for surgical incisions.

Keyword

Wound healing; Aloe; Thyroid hormones; Silver sulfadiazine; Wistar rats

MeSH Terms

Administration, Topical
Aloe
Animals
Blood Vessels
Dermis
Epithelium
Fibroblasts
Glycosaminoglycans
Humans
Macrophages
Male
Neutrophils
Rats
Rats, Wistar
Re-Epithelialization
Silver Sulfadiazine
Thyroid Gland
Thyroid Hormones
Wound Healing
Glycosaminoglycans
Silver Sulfadiazine
Thyroid Hormones
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