Korean J Dermatol.  2015 Aug;53(7):556-559.

Squamous Cell Carcinoma Originating from Frostbite-induced Osteomyelitis

• Hwangbo H
• Lee TG
• Jung SW
• Son HH
• Lee SK

Abstract

Squamous cell carcinoma commonly originates from recalcitrant wound sites, including burn scars, pressure sores, stasis ulcers, osteomyelitis, and sites of frostbite. A 62-year-old male was referred to the dermatology department for skin necrosis of his right great toe and walking difficulty. He had a history of smoking, drinking alcohol, and frostbite of his right great toe 9 years prior, which deteriorated into osteomyelitis due to poor care. Although a skin biopsy was recommended before amputation, the two procedures were performed simultaneously due to a lack of toe function due to severe osteolysis. Biopsy of the amputated toe tip showed many lobules consisting of atypical keratinocytes with hyperchromatic nuclei, and severe dermal pleomorphism. After evaluation for distant metastasis, including a (99m) Tc-MDP bone scan, 18F-FDG positron emission tomography scan, computed tomography, and ultrasound, no metastasis was detected.

Keyword

Squamous cell carcinoma; Osteomyelitis; Frostbite

MeSH Terms

Amputation
Biopsy
Burns
Carcinoma, Squamous Cell*
Cicatrix
Dermatology
Drinking
Fluorodeoxyglucose F18
Frostbite
Humans
Keratinocytes
Male
Middle Aged
Necrosis
Neoplasm Metastasis
Osteolysis
Osteomyelitis*
Positron-Emission Tomography
Pressure Ulcer
Skin
Smoke
Smoking
Toes
Ultrasonography
Varicose Ulcer
Walking
Wounds and Injuries
Fluorodeoxyglucose F18
Smoke