Korean J Dermatol.
2015 Aug;53(7):542-545.
A Case of Drug Eruption Similar to Erythema Multiforme Induced by Sorafenib
- Affiliations
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- 1Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea. mnkim@cau.ac.kr
Abstract
- Sorafenib is an oral multi-kinase inhibitor with effects on tumor cell proliferation and tumor angiogenesis. The drug is associated with a relatively high incidence of dermatologic adverse events. Frequently observed clinical presentations include skin rash, a hand-foot skin reaction, alopecia, splinter subungual hemorrhages, and xerosis. There have been few reports of erythema multiforme or leukocytoclastic vasculitis related to sorafenib use. We report a case of a 72 year-old male diagnosed with renal cell carcinoma with distant metastasis, who developed an erythema multiforme-like drug eruption on his trunk and extremities after use of sorafenib.