Korean J Dermatol.  2015 Aug;53(7):542-545.

A Case of Drug Eruption Similar to Erythema Multiforme Induced by Sorafenib

Affiliations
  • 1Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea. mnkim@cau.ac.kr

Abstract

Sorafenib is an oral multi-kinase inhibitor with effects on tumor cell proliferation and tumor angiogenesis. The drug is associated with a relatively high incidence of dermatologic adverse events. Frequently observed clinical presentations include skin rash, a hand-foot skin reaction, alopecia, splinter subungual hemorrhages, and xerosis. There have been few reports of erythema multiforme or leukocytoclastic vasculitis related to sorafenib use. We report a case of a 72 year-old male diagnosed with renal cell carcinoma with distant metastasis, who developed an erythema multiforme-like drug eruption on his trunk and extremities after use of sorafenib.

Keyword

Drug eruption; Erythema multiforme; Sorafenib

MeSH Terms

Alopecia
Carcinoma, Renal Cell
Cell Proliferation
Drug Eruptions*
Erythema Multiforme*
Erythema*
Exanthema
Extremities
Hemorrhage
Humans
Incidence
Male
Neoplasm Metastasis
Skin
Vasculitis
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