Ann Lab Med.  2015 Jul;35(4):469-471. 10.3343/alm.2015.35.4.469.

Identification of Mixed Lineage Leukemia Gene (MLL)/MLLT10 Fusion Transcripts by Reverse Transcription-PCR and Sequencing in a Case of AML With a FISH-Negative Cryptic MLL Rearrangement

• Ko K
• Kwon MJ
• Woo HY
• Park H
• Park CH
• Lee ST
• Kim SH

• KMID: 2045874
• DOI: http://doi.org/10.3343/alm.2015.35.4.469

Abstract

No abstract available.

MeSH Terms

Leukemia*

Figure

• 

  Fig. 1 Bone marrow karyotype showing derivative chromosomes 10 and 12 with an apparently normal chromosome 11. Karyotype: 46,XY,der(10)t(10;21)(p12;q21),der(12)del(12)(p11.2)add(12)(q24.2)[17]/46,XY[3].

• 

  Fig. 2 Two fusion signals (2F) with no MLL break-apart signals. LSI MLL (B-A) probe: LSI MLL dual-color, break-apart rearrangement probe.Abbreviation: MLL, mixed lineage leukemia gene.

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  Fig. 3 Identification of the MLL/MLLT10 fusion transcript in acute myeloid leukemia. Sequencing analyses confirmed that the transcript was from MLL (exon 8)-MLLT10 (exon 16) rearrangement.Abbreviation: MLL, mixed lineage leukemia gene.

Reference

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