J Korean Pediatr Soc.  1993 Oct;36(10):1434-1440.

Plasma immunoreactive endothlin-1, creatine kinase and CK isoenzyme and its relation to neonate with asphyxia

• Lee KW
• Lee KH
• Son CS
• Tockgo YC

Abstract

Endotheline-1 (ET-1) is a potent vasoconstrictor peptide with 21 amino acid residues. ET-1 is thought to have a key role in vasoconstriction, and cardiac, renal, and endocrine actions of the peptide. Creatine Kinase(CK), also referred to as ATP-creatine-N-phosphotransferase, consists of either the B or M type. CK is found almost exclusively in muscle(MM), myocardium(MB), and brain(BB). It is to be an almost specific index of injury of myocardium and brain in hypoxic damage. I measured the ET-1, CK isoenzyme in neonates among asphyxia group (14 cases), as a control devide into two group. 1st group(birth weight (2500 g, n=9) and 2nd group (body weight 2500g, n=11). 1) There was no significant difference between asphyxia and control 1st, 2nd group during postnatal 24 hrs include cord blood on irET-1(p< 0.05). 2) There was significant difference between asphyxia and control 1 st, 2nd group during postnatal 24 hrs include cord blood on CK and CK and CK isoenzyme (p<0.001). 3) There was significant difference between asphyxia and control 1st, 2nd group on CK-MB and CK-BB proportion (p< 0.001). 4) There was significant difference between cord blood and postnatal 24 hrs on total CK level (P< 0.001).

Keyword

Asphyxia; irET-1; CK and CK isoenzyme

MeSH Terms

Asphyxia*
Brain
Creatine Kinase*
Creatine*
Fetal Blood
Humans
Infant, Newborn*
Myocardium
Plasma*
Vasoconstriction
Creatine
Creatine Kinase