Korean J Blood Transfus.  2003 Dec;14(2):160-172.

The Frequency of Unexpected Antibodies in Blood Donors and Transfusion Candidates in Korea

Affiliations
  • 1Korean Red Cross Blood Center.
  • 2Korean Red Cross Blood Transfusion Institute.
  • 3Seoul National University College of Medicine.
  • 4Yonsei University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND: A retrospective study was performed to estimate the frequency of red cell antibodies in blood donors (n=1,620,023) and transfusion candidates (SNUH n=12,111, YUMH n=26,665) for last 2 years (2000~2001). The results of the antibody screening and identification tests, the frequency and specificities of antibodies identified compared with blood centers and two hospitals had been used the different test methods each others. METHOD: Blood centers had been used tube and micro-plate method simultaneously with an in house and commercial panels. SNUH had been used micro-plate method using V plate with an in house and commercial panels. YUMH had been used gel agglutination technique (DiaMed ID System : DiaMed, Murten; Switzerland) since 1998.
RESULTS
The frequencies of red blood cell antibodies were 0.26% (4,204 / 1,620,023 donor sera ), 0.11% (135 / 12,111 patient sera in SNUH) and 0.48% (128 / 26,665 patient sera in YUMH). Female donors and old ages showed higher frequency of red cell antibodies than male and young ages. Most of antibodies detected in donors were clinically less relevant antibodies such as Anti-Lea and Leb (38.9%), anti-P1 (18.1%), anti-H(IH) (8.4%), anti-M (6.2%) and so on. Clinically significant antibodies including Rh system antibodies (2.0%) were few, and composed only 12% of all the antibodies detected. In patients, clinically relevant antibodies including Rh antibodies (40.4% in SNUH, 71.9% in YUMH) were more frequently observed comparing with in donors.
CONCLUSION
Antibodies found in donors were mostly clinically less relevant. Antibody screening method used in blood centers would be standardized. Blood banks using gel technique showed high detection rate of clinically significant antibodies comparing with facilities using other methods.

Keyword

Unexpected antibodies; Antibody screening test; Antibody identification test; Micro-plate method; Tube method; Antibody specificity; Gel-agglutination technique

MeSH Terms

Agglutination
Antibodies*
Antibody Specificity
Blood Banks
Blood Donors*
Erythrocytes
Female
Humans
Korea*
Male
Mass Screening
Retrospective Studies
Tissue Donors
Antibodies
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