Korean J Dermatol.  2013 Jan;51(1):40-44.

Transient Bullous Dermolysis of the Newborn

• Jeon IK
• Kim SC

Abstract

Transient bullous dermolysis of the newborn (TBDN) is a rare subtype of the dystrophic epidermolysis bullosa characterized by blistering at birth which improves spontaneously during early life. Electron microscopy showed sublamina densa separation with dilated rough endoplasmic reticulum and electron dense inclusions. Immunofluorescence mapping using anti-type VII collagen antibody showed widespread intraepidermal type VII collagens which are a characteristic finding of TBDN. Here, we report two cases of TBDN presenting typical clinical manifestations, electron microscopy findings, and immunofluorescence mapping results. The skin lesions of both patients healed spontaneously 2~3 months later.

Keyword

Dystrophic epidermolysis bullosa; Transient bullous dermolysis of the newborn

MeSH Terms

Blister
Collagen
Collagen Type VII
Electrons
Endoplasmic Reticulum, Rough
Epidermolysis Bullosa Dystrophica
Fluorescent Antibody Technique
Humans
Infant, Newborn
Microscopy, Electron
Parturition
Skin
Collagen
Collagen Type VII
Epidermolysis Bullosa Dystrophica