Korean J Otolaryngol-Head Neck Surg.  2005 Feb;48(2):260-262.

Two Cases of Metachronous Squamous Cell Carcinoma Involving Both Maxillary Sinuses

  • 1Department of Otolaryngology College of Medicine, Pusan National University, Busan, Korea. rohhj@pusan.ac.kr


Malignant tumors of the nasal cavities and paranasal sinuses are uncommon, comprising less than one percent of all tumors. Although multiple primary carcinoma of the aerodigestive tract are commonly reported, metachronous squamous cell carcinomas of both maxillary sinuses are extremely rare. The incidence of metachronous maxillary carcinoma involving both sinuses is 1.2-1.4 percent of all patients with maxillary carcinoma. Here we present two cases of metachronous squamous cell carcinoma involving both maxillary sinuses, which are the first reported cases in Korea. A 74-year-old female and 56-year-old male had right maxillary cancer. They had additional carcinoma developed in the contralateral maxillary sinus after 6 years and 12 years, respectively. Although the possibility is rare, metachronous tumors of the contralateral maxillary sinus can occur. An early dianosis and appropriate treatment of the secondary lesion is critical.


Neoplasms; Second primary; Maxillary sinus
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