Korean J Anesthesiol.  2013 Aug;65(2):114-120. 10.4097/kjae.2013.65.2.114.

Preanesthetic dexmedetomidine 1 microg/kg single infusion is a simple, easy, and economic adjuvant for general anesthesia

• Shin HW
• Yoo HN
• Kim DH
• Lee H
• Shin HJ
• Lee HW

• KMID: 2031251
• DOI: http://doi.org/10.4097/kjae.2013.65.2.114

Abstract

BACKGROUND
Dexmedetomidine is an alpha2-adrenoreceptor agonist with sedative, analgesic and anxiolytic effects, and it has more selective alpha2-adrenergic effect than clonidine. We evaluate the effect of preansethetic dexmedetomidine 1 microg/kg single infusion on sedation, hemodynamics, anesthetic consumption, and recovery profiles during anesthesia.
METHODS
Forty-two female patients with American Society of Anesthesiologists physical status I or II undergoing gynecologic surgery with anticipated operation time of 2 h, were randomly assigned to receive dexmedetomidine 1 microg/kg (Dex group) or saline (control group) iv over 10 min before anesthetic induction. After tracheal intubation with propofol 2 mg/kg, cisatracurium 0.15 mg/kg iv, anesthesia was maintained with sevoflurane, O2 50%, N2O 50% around a BIS value of 40.
RESULTS
After study drug infusion, BIS of Dex group was lower than that of control group (93.9 +/- 3.1 vs 51.5 +/- 5.2, P < 0.05). Mean arterial pressure (MAP) and heart rate (HR) after intubation were increased in control group, but did not change in Dex group. During maintenance, there was no difference in MAP between groups, but HR of Dex group was lower compared to that of control group. End-tidal concentration (2.0 +/- 0.5 vol% vs 1.4 +/- 0.3 vol%, P < 0.05) and total cumulative consumption of sevoflurane (34.6 +/- 3.8 ml vs 26.5 +/- 5.3 ml, P < 0.05) were lower in Dex group than in control group. Recovery profiles, modified Aldrete score, postoperative nausea vomiting, and visual analogue pain score were not significantly different between groups.
CONCLUSIONS
Preanesthetic dexmetomidine 1 microg/kg single infusion is a simple, easy, and economic general anesthetic adjuvant that maintains stable hemodynamics and decrease anesthetic consumption without the change of recovery profiles.

Keyword

Dexmedetomidine; Economics; Hemodynamics; Recovery of function; Sevoflurane

MeSH Terms

Anesthesia
Anesthesia, General
Anti-Anxiety Agents
Arterial Pressure
Atracurium
Clonidine
Dexmedetomidine
Female
Gynecologic Surgical Procedures
Heart Rate
Hemodynamics
Humans
Intubation
Methyl Ethers
Postoperative Nausea and Vomiting
Propofol
Recovery of Function
Vomiting
Anti-Anxiety Agents
Atracurium
Clonidine
Dexmedetomidine
Methyl Ethers
Propofol