Korean J Clin Pathol.  1999 Oct;19(5):500-503.

A Case of Transient Pancytopenia Preceding Childhood Acute Leukemia

  • 1Department of Clinical Pathology, Seoul National University College of Medicine, Seoul, Korea
  • 2Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea


Transient pancytopenia preceding acute lymphoblastic leukemia is an infrequent but well-known event, especially in childhood. We report a case of childhood acute leukemia preceded by transient pancytopenia and hepatitis. A seven-year-old boy presented with pancytopenia and hepatomegaly. He had suffered from fever, generalized rash, and jaundice for one week. His clinical symptoms and laboratory data normalized within two weeks. One and a half months later, however, he developed multiple lymphadenopathy and hepatomegaly, and follow-up bone marrow study revealed acute leukemia. The blasts were counted up to 92% of all nucleated cells in bone marrow, and showed lymphoid feature confirmed by the cytochemical reactions. Immunophenotypically, it was acute biphenotypic leukemia with positivity of CD13, CD33, CD19, CD10, CD34, HLA-DR, and terminal deoxynucleotidyl transferase. In conclusion, this is the first report of childhood leukemia preceded by pancytopenia in Korea, characteristically with the biphenotypic feature and the rare association with hepatitis.


Pancytopenia; Acute leukemia; Biphenotype; Hepatitis
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