Korean Circ J.  2011 Apr;41(4):198-202. 10.4070/kcj.2011.41.4.198.

Relationship Between Plasma Adiponectin, Retinol-Binding Protein 4 and Uric Acid in Hypertensive Patients With Metabolic Syndrome

• Park CS
• Ihm SH
• Park HJ
• Shin WS
• Kim PJ
• Chang K
• Kim HY
• Youn HJ
• Chung WS
• Seung KB
• Kim JH

• KMID: 2028944
• DOI: http://doi.org/10.4070/kcj.2011.41.4.198

Abstract

BACKGROUND AND OBJECTIVES
Adipokines have been suggested for their potential use in tracking the clinical progress in the subjects with metabolic syndrome (MS). To investigate the relationship between the serum levels of adipokines {adiponectin and retinol-binding protein 4 (RBP4)} and the serum level of uric acid in hypertensive (HTN) patients with MS.
SUBJECTS AND METHODS
In this study, 38 totally untreated HTN patients were enrolled. Anthropometric measurements, blood pressure (BP) were taken in the 12 HTN patients without MS and the 26 HTN patients with MS. Fasting blood samples were collected for measurement of adiponectin, RBP4, nitric oxide (NO), glucose, creatinine, uric acid, lipid profile and insulin.
RESULTS
The HTN with MS group had significant higher values of body mass index, waist length, serum uric acid and triglyceride levels than the HTN without MS group. Compared to the HTN without MS group, the HTN with MS group showed significantly lower adiponectin (p=0.030), NO (p=0.003) and high density lipoprotein levels (p<0.001). Serum adiponectin levels negatively correlated with insulin level (R=-0.453, p=0.026) and uric acid level (R=-0.413, p=0.036), and serum RBP4 levels positively correlated with uric acid level (R=0.527, p=0.006) in the HTN with MS group. Multiple linear regression analysis using RBP4 and adiponectin levels as the dependent variables showed that uric acid level correlated with serum RBP4 level (p=0.046) and adiponectin level (p=0.044).
CONCLUSION
The HTN with MS group showed a correlation with two types of adipokines (adiponectin, RBP4) and uric acid. Adiponectin, RBP4 and uric acid may be important components associated with MS, especially when associated with hypertension.

Keyword

Adiponectin; Retinol-binding protein 4; Uric acid; Hypertension; Metabolic syndrome

MeSH Terms

Adipokines
Adiponectin
Blood Pressure
Body Mass Index
Creatinine
Fasting
Glucose
Humans
Hypertension
Insulin
Linear Models
Lipoproteins
Nitric Oxide
Plasma
Track and Field
Uric Acid
Adipokines
Adiponectin
Creatinine
Glucose
Insulin
Lipoproteins
Nitric Oxide
Uric Acid

Figure

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  Fig. 1 The relationship between the plasma adiponectin and uric acid in the hypertensive patients with metabolic syndrome.

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  Fig. 2 The relationship between the plasma RBP and uric acid in the hypertensive patients with metabolic syndrome.

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