Korean Circ J.  2012 May;42(5):345-348. 10.4070/kcj.2012.42.5.345.

Recurrent Deep Vein Thrombosis due to Thrombophilia

  • 1Department of Cardiology, Sir Salimullah Medical College & Mitford Hospital, Dhaka, Bangladesh.
  • 2Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh. drmonwarbd@yahoo.com
  • 3Department of Cardiology, Zia Heart Foundation Hospital and Research Institute, Dinajpur, Bangladesh.


Deep vein thrombosis (DVT) is a common condition that is often under-diagnosed. Acquired or hereditary defects of coagulation or a combination of these defects may facilitate the development of DVT. Recurrent DVT, a positive family history or unusual presentation may warrant investigation for hereditary thrombophilia. Investigations are best when conducted at least one month after completion of a course of anticoagulant therapy. Most patients are managed with heparin in the acute stage overlapped by warfarin. The case presented here describes a 40-year old man undergoing three episodes of DVT. Investigations revealed protein C and protein S deficiency. Protein C, protein S and antithrombin deficiency either singly or in combination, are relatively common causes of hereditary thrombophilia. The case presented here serves as a reminder of the need to look into the underlying cause of venous thromboembolism.


Deep vein thrombosis; Thrombophilia

MeSH Terms

Protein C
Protein S
Protein S Deficiency
Venous Thromboembolism
Venous Thrombosis
Protein C
Protein S


  • Fig. 1 Left popliteal venous thrombosis.

  • Fig. 2 Incompletely recanalized left external iliac vein.

  • Fig. 3 Incompletely recanalized left common femoral vein.

  • Fig. 4 Normal pulmonary arteries shown on the CT angiogram.


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