Korean J Occup Environ Med.  1994 Feb;6(1):56-68.

Changes in Cadmium Deposit and Histopathologic Finding of Testis, Liver and Kidney in Cadmium Exposed Rats

• Lee YG
• Park JD
• Choi BS
• Hong YP
• Chang IW

Abstract

To assess the changes of cadmium deposit and histopathologic finding of testis, liver and kidney, different dose of cadmium (Cd) was administered into male Sprague-Dawley rat(purchased from KIST, Korea Institute of Science and Technology) by single intravenous injection. At 12, 24, 48, 168 and 672 hours after Cd injection, tissue cadmium concentration and histopathological change were examined. Cd exposed group showed lesser weight gain than the control. Renal Cd content tended to increase in time-dependent pattern, while hepatic and testicular Cd content tended to decrease. Mean of renal Cd content to hepatic Cd content (Cd K/Cd L) also progressively increased. These results suggest that Cd might be gradually transported to kidney fro other organs. In testis and liver, degenerative changes appeared relatively in acute phase. These changes became more pronounced in testis, while less prominent in liver. In kidney, swelling of proximal tubluar cells and thickening of glomerular basement membrane appeared relatively later and these changes were progressively aggravated.

Keyword

Cadmium deposit; Histopathologic finding; Time-dependent; Testis; Liver; Kidney; Cd K/Cd L

MeSH Terms

Animals
Cadmium*
Glomerular Basement Membrane
Humans
Injections, Intravenous
Kidney*
Korea
Liver*
Male
Rats*
Rats, Sprague-Dawley
Testis*
Weight Gain
Cadmium