J Periodontal Implant Sci.  2012 Apr;42(2):33-38. 10.5051/jpis.2012.42.2.33.

Antiplaque and antigingivitis effects of a mouthrinse containing cetylpyridinium chloride, triclosan and dipotassium glycyrrhizinate

• Shim JY
• Yim SB
• Chung JH
• Hong KS

• KMID: 2027784
• DOI: http://doi.org/10.5051/jpis.2012.42.2.33

Abstract

PURPOSE
The goal of this study was to evaluate the clinical anitplaque and antigingivitis effects of a mouthrinse containing cetylpyridinium chloride (CPC), triclosan and dipotassium glycyrrhizinate (DPZ) in patients with gingivitis and mild periodontitis.
METHODS
Thirty-two subjects were randomized into 2 groups. The test group used a mouthrinse containing 0.05% CPC, 0.02% triclosan and 0.02% DPZ, while the control group used a placebo mouthrinse. At baseline, 2 weeks and 4 weeks, the papillary bleeding index (PBI), Turesky-Quigley-Hein plaque index (PI) and Loe-Silness gingival index (GI) were assessed. During the experimental period, the patients used the mouthrinse for 30 seconds, 4 to 5 times/day (10 mL/time) within 30 minutes after toothbrushing.
RESULTS
No adverse effects appeared in either the experimental or the control group. Regarding PBI, PI and GI values, statistical significance was detected between values at baseline and 2 weeks for both groups (P<0.05). In the experimental group, statistically significantly lower values were detected at 4 weeks compared to at 2 weeks. However, in the control group, no statistically significant difference was detected between the values at 2 weeks and 4 weeks. Additionally, the mean value after 4 weeks for the control group was slightly higher than the mean value after 2 weeks for the control group.
CONCLUSIONS
This study for 4 weeks demonstrated that mouthrinses containing CPC, triclosan and DPZ may contribute to the reduction of supragingival plaque and gingivitis.

Keyword

Cetylpyridinium; Dental plaque index; Glycyrrhizic acid; Prevention mouthrinse; Triclosan

MeSH Terms

Cetylpyridinium
Citrates
Dental Plaque Index
Dinucleoside Phosphates
Drug Combinations
Gingivitis
Glycyrrhizic Acid
Hemorrhage
Humans
Hydrogen Peroxide
Periodontal Index
Sulfates
Triclosan
Zinc Compounds
Cetylpyridinium
Citrates
Dinucleoside Phosphates
Drug Combinations
Glycyrrhizic Acid
Hydrogen Peroxide
Sulfates
Triclosan
Zinc Compounds

Figure

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  Figure 1 Experimental protocol.

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  Figure 2 Papillary bleeding index. a)Statistically significant (P<0.05).

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  Figure 3 Plaque index. a)Statistically significant (P<0.05).

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  Figure 4 Gingival index. a)Statistically significant (P<0.05).

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