J Korean Rheum Assoc.  1996 Jan;3(1):76-80.

Two Cases of Scleroderrna with Peripheral Vascular diseases

Affiliations
  • 1Department of internal Medicine, College of Medicine, Korea University, Seoul, Korea.

Abstract

Scleroderma is a systemic disorder with multiorgan involvement. About 90% of patients with scleroderma has Raynaud's phenomenon and microvascular involvement is well recognized in scleroderma, but macrovascular involvement is not recognized. We experienced 2 cases of scleroderma with peripheral vascular occlusions that had been diagnosed by fernoral angiography. The one patient with limited scleroderma had anticentromere antibody and angiography of both fernoral arteries showed nonvisualization of posterior tibial artery. The other patient with diffuse scleroderma had anti-Scl-70 antibody and angiography of right fernoral artery showed occlusion of both anterior and posterior tibial arteries and stenosis of distal portion of peronial artery. Both patients didn't have the risk factors of atherosclerosis such as hypertension, hypercholesterolemia, obesity, and smoking. In recent years, there have been reports that scleroderma is associated with macrovascular disease. In the future, the study on the freguency, prevention and treatment of macrovasular disease in scleroderma is necessary. We report 2 cases of scleroderma with peripheral vascular occlusions that had been diagnosed by fernoral angiography with review of literatures.

Keyword

Scleroderma; Peripheral vascular disease

MeSH Terms

Angiography
Arteries
Atherosclerosis
Constriction, Pathologic
Humans
Hypercholesterolemia
Hypertension
Obesity
Peripheral Vascular Diseases*
Risk Factors
Scleroderma, Diffuse
Scleroderma, Limited
Smoke
Smoking
Tibial Arteries
Smoke
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