J Korean Geriatr Soc.  2001 Dec;5(4):348-353.

A Case of CHAP Syndrome

Abstract

CHAP syndorme consists of choreoathetosis, orofacial dyskinesia, affective change, hypotonia, and pseudobulbar signs. CHAP syndrome was firstly des- cribed with onset 1 to 7 days after induced profound hypothermia and complete circulatory arrest for con- genital heart lesion repair. Since then, only a few cases have been reported until now. Case We report a patient who demonstrated all of the elements of the CHAP syndrome in severe cachexic state. Brain SPECT(99mTC-ECD) shows decreased perfusion in left fronto-parieto-temporal lobe. Comments The pathogenesis of CHAP syndrome is obscure. However our case led us to suggest that more essential component pre- disposing to the CHAP syndrome is hypoxia rather than hypothermia. Furthermore, it seems to be related with circulatory insufficiency in extrapyramidal nervous systems.

Keyword

Choreoathetosis; Orofacial dyskinesia; Hypotonia; Pseudobular signs

MeSH Terms

Anoxia
Brain
Heart
Humans
Hypothermia
Movement Disorders
Muscle Hypotonia
Nervous System
Perfusion
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