J Korean Diabetes Assoc.  1997 Jun;21(2):130-137.

Thebeta3-adrenergic Receptor Gene Polymorphism in Non-Insulin Dependent Diabetes Mellitus

• Lee JH
• Li HR
• Lee SW
• Nam SY
• Won YJ
• Cha BS
• Nam MS
• Song YD
• Lee EJ
• Lim SK
• Kim KR
• Lee HC
• Huh KB

Abstract

BACKGROUND: The B3-adrenergic receptor, located mainly in adipose tissue, is known to be involved in the regulation of lipolysis and thermogenesis. Recently studies have shown that the B3-adrenergic receptor gene polymorphism is associated with Non-Insulin Dependent Diabetes Mellitus(NIDDM) and insulin resistance. We investigated the relationship between the B3-adrenergic receptor gene polymorphism and the cli!ical and biochemical features of NIDDM patients.
METHODS
Anthropometeric and biochemi al characteristics were determined for 134 NIDDM subjects and 30 nondiabetic controls. All subjects were genotyped for the 0-adrenergic receptor gene mutation using restriction fragment length polymorphism assay.
RESULTS
The allelic frequency of the mutated allele was similar in NIDDM subjects and nondiabetic controls(11%, 12% respectively). There was no difference in the Arg64 allelic frequency of the B3-adrenergic receptor gene according to the onset age of diabetes. In diabetic group, the clinical and biochemical characteristics were not statistically different between the B3-adrenergic receptor gene mutation and nonmutation group. In control group, also no clinical differences were found between mutation and non-mutation group. When comparing frequency of obesity according to the B3-adrenergic receptor gene mutation in diabetic patients, we did not find the difference between the two groups.
CONCLUSION
These results suggest that the b3-adrenergic receptor gene is not a major determinant for the development of obesity and NIDDM in Korea.

MeSH Terms

Adipose Tissue
Age of Onset
Alleles
Diabetes Mellitus*
Diabetes Mellitus, Type 2
Humans
Insulin Resistance
Korea
Lipolysis
Obesity
Polymorphism, Restriction Fragment Length
Thermogenesis