J Korean Soc Radiol.  2013 Jul;69(1):5-10. 10.3348/jksr.2013.69.1.5.

Computational Fluid Dynamics of Intracranial Artery Using 3-Dimensional Angiography: Potentials and Technical Considerations

• Choi SY
• Park ST
• Yoon K
• Ko YB
• Suh DC

• KMID: 2002884
• DOI: http://doi.org/10.3348/jksr.2013.69.1.5

Abstract

We report the potentials and limitations of computational fluid dynamics (CFD) analysis of patient-specific intracranial model with modification of proximal and distal length. Flow pattern does not seem to be affected by the length of proximal internal carotid artery. However, most of the flow was directed to the shorter distal part. Our study could serve as a technical reference to validating other tools and CFD results.

MeSH Terms

Angiography
Arteries
Carotid Artery, Internal
Cerebral Arteries
Hydrodynamics

Figure

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  Fig. 1 Work flow of computational fluid analysis. Note.-CFD = computational fluid dynamics, STL = standard template library, 3D = 3-dimensional

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  Fig. 2 Original and modified models shows changes of velocity at individual vessels. A. Original 3-dimensional model. Computational fluid dynamics analysis shows velocity cut surface in systolic phase. B. Original model. C. Short middle cerebral artery (arrow) model. D. Short proximal model. E. Proximal elongated model

Reference

1. Milnor WR. Hemodynamics. 2nd ed. Baltimore, MD: Williams & Wilkins;1989.

2. Younis HF, Kaazempur-Mofrad MR, Chan RC, Isasi AG, Hinton DP, Chau AH, et al. Hemodynamics and wall mechanics in human carotid bifurcation and its consequences for atherogenesis: investigation of inter-individual variation. Biomech Model Mechanobiol. 2004; 3:17–32.

3. Cebral JR, Mut F, Weir J, Putman CM. Association of hemodynamic characteristics and cerebral aneurysm rupture. AJNR Am J Neuroradiol. 2011; 32:264–270.

4. Suh DC, Park ST, Oh TS, Park SO, Lim OK, Park S, et al. High shear stress at the surface of enhancing plaque in the systolic phase is related to the symptom presentation of severe M1 stenosis. Korean J Radiol. 2011; 12:515–518.

5. Nakatani H, Hashimoto N, Kang Y, Yamazoe N, Kikuchi H, Yamaguchi S, et al. Cerebral blood flow patterns at major vessel bifurcations and aneurysms in rats. J Neurosurg. 1991; 74:258–262.

6. Park ST, Kim JK, Yoon KH, Park SO, Park SW, Kim JS, et al. Atherosclerotic carotid stenoses of apical versus body lesions in high-risk carotid stenting patients. AJNR Am J Neuroradiol. 2010; 31:1106–1112.

7. Goubergrits L, Thamsen B, Berthe A, Poethke J, Kertzscher U, Affeld K, et al. In vitro study of near-wall flow in a cerebral aneurysm model with and without coils. AJNR Am J Neuroradiol. 2010; 31:1521–1528.

8. Cebral JR, Mut F, Raschi M, Scrivano E, Ceratto R, Lylyk P, et al. Aneurysm rupture following treatment with flow-diverting stents: computational hemodynamics analysis of treatment. AJNR Am J Neuroradiol. 2011; 32:27–33.