J Korean Acad Periodontol.  2005 Jun;35(2):335-343. 10.5051/jkape.2005.35.2.335.

A study on the safety and efficacy of bovine bone-derived bone graft material(OCS-B)

• Park HN
• Han SH
• Kim KH
• Lee SC
• Park YJ
• Lee SH
• Kim TI
• Seol YJ
• Ku Y
• Rhyu IC
• Han SB
• Chung CP

• KMID: 1999762
• DOI: http://doi.org/10.5051/jkape.2005.35.2.335

Abstract

Inorganic bovine bone mineral has been widely researched as bone substitution materials in orthopedic and oral and maxillofacial application. OCS-B(NIBEC, Korea) is newly-developed inorganic bovine bone mineral. The aim of this study is to evaluate the safety and efficacy of bovine bone-derived bone graft material(OCS-B). Micro-structure of newly-developed inorganic bovine bone mineral(OCS-B) was analyzed by scanning electron microscope(SEM). Round cranial defects with eight mm diameter were made and filled with OCS-B in rabbits. OCS-B was inserted into femoral quadrant muscle in mouse. In scanning electron microscope, OCS-B was equal to natural hydroxyapatite. Rabbits were sacrificed at 2 weeks and 4 weeks after surgery and mice were sacrificed at 1 week and 2 weeks after surgery. Decalcified specimens were prepared and observed by microscope. In calvarial defects, osteoid and new bone were formed in the neighborhood of OCS-B at 2 weeks after surgery. And at 4 weeks after surgery osteoid and new bone bridge formed flourishingly. No inflammatory cells were seen on the surface of OCS-B at 1 week and 2 weeks in mouse experimental group. It is concluded that newly-developed inorganic bovine bone mineral(OCS-B) is a flourishing bone-forming material and biocompatible material.

Keyword

bovine bone; bone regeneration; calvarial defect

MeSH Terms

Animals
Bone Regeneration
Durapatite
Mice
Orthopedics
Rabbits
Residence Characteristics
Transplants*
Durapatite