Korean J Thorac Cardiovasc Surg.  1997 Jun;30(6):573-579.

An Experimental Model of Isolated Lung Block for Evaluation of Pulmonary Preservation after Ischemia

• Sung SW
• Lim C
• Kim YT
• Park JH

Abstract

During the last 30 years, major organ transplantation has become popular, even in Korea, such as kidney, liver, etc. After the successful clinical cardiac transplantation in Korea, many cases of cardiac transplantation are being performed in some centers. But lung transplantation has a lot of obstacles, especially donor shortage and decreased tolerability of the lung to ischemia-reperfusion injury. Usually it was considered that the maximum safety margin of ischemic time in lung transplantation was about 4 to 6 hours. So, many investigators have tried to develop better preservation methods and experimental model for evaluation of effectiveness in those various methods. But most of those methods had several drawbacks in clinical and experimental settings. So we developed an easily-controllable, reliable, and inexpensive experimental model of isolated rabbit lung block. Using these model, we evaluated its effectiveness and reliability for the experiment of ischemia-reperfusion injury in lung transplantation.

Keyword

Lung preservation; Transplantation

MeSH Terms

Heart Transplantation
Humans
Ischemia*
Kidney
Korea
Liver
Lung Transplantation
Lung*
Models, Theoretical*
Organ Transplantation
Reperfusion Injury
Research Personnel
Tissue Donors
Transplantation
Transplants