Korean J Med.  2005 Jul;69(1):55-60.

Factors related to prevalence of colonic polyps in acromegalic patients

• Lee SW
• Park SH
• Lee JY
• Jeong GH
• Chung SC
• Kim JG
• Ha SW
• Kim BW

Abstract

BACKGROUND: It has been suggested that acromegalic patients are at increased risk of developing colonic neoplasia. We evaluated the prevalence of colonic neoplasia and the relationships of clinical parameters of acromegalic activity with presence of colonic neoplasia in Korean acromegalic patients.
METHODS
In 30 patients with active acromegaly, colonoscopy was performed at the time of diagnosis. According to the endoscopic findings and histological classifications, the patients were grouped, and a number of clinical parameters of acromegalic activity were compared between those with and without colonic polyps.
RESULTS
Colonic polyps were detected in 17 (56.7%) in the 30 acromegalic patients with colonoscopic examinations; 7 (23.3%) hyperplastic and 10 (33.3%) adenomatous polyps. Those with colonic polyps were significantly older (52.2+/-9.46 years vs. 42.2+/-12.97 years, p=0.02) and also had significantly longer disease duration (11.8+/-7.52 years vs. 5+/-2.20 years, p=0.004) than those without ones. In 21 patients who were more than 40 years old, significant differences were found in disease duration (12.7+/-7.54 years vs. 5.0+/-2.68 years, p=0.026) and serum IGF-1 level (1311.9+/-500.14 ng/mL vs. 715.9+/-330.58 ng/mL, p=0.015) between those with and without colonic polyps.
CONCLUSION
These results suggest that screening colonoscopy should be recommended in acromegalic patients who are more than 40 year-old, have long disease duration or have high serum IGF-1 level.

Keyword

Acromegaly; Colonic polyps; Disease duration; Insulin-like growth factor-1

MeSH Terms

Acromegaly
Adenomatous Polyps
Adult
Classification
Colon*
Colonic Polyps*
Colonoscopy
Diagnosis
Humans
Insulin-Like Growth Factor I
Mass Screening
Prevalence*
Insulin-Like Growth Factor I