Korean J Pain.  2013 Apr;26(2):125-129. 10.3344/kjp.2013.26.2.125.

Effects of Palonosetron, a 5-HT3 Receptor Antagonist, on Mechanical Allodynia in a Rat Model of Postoperative Pain

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, School of Medicine, Chosun University, Gwangju, Korea. kjlim@chosun.ac.kr
  • 2Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University, Gwangju, Korea.

Abstract

BACKGROUND
5-hydroxytryptamine 3 (5-HT3) receptors have been known to be associated with the modulation of nociceptive transmission. However, it is uncertain whether 5-HT3 plays a role in the antinociceptive or pronociceptive pathway for incisional pain. In this study, we evaluated the effects of palonosetron, a 5-HT3 receptor antagonist, on incisional pain in rats when administered intrathecally or intraplantarly.
METHODS
An intrathecal catheter was implanted through the cisterna magna and placed in the intrathecal space of rats. An incision in the plantaris muscle of the right hind paw was done under anesthesia with sevoflurane. Withdrawal thresholds were evaluated with the von Frey filament after 2 hours. Palonosetron (0.5 and 0.1 microg intrathecally; 0.5 microg intraplantarly) was administered and the thresholds were observed for 4 hours.
RESULTS
Mechanical hypersensitivity developed after the incision. Intrathecal palonosetron (0.5 microg and 0.1 microg) did not alter the paw withdrawal threshold. Intraplantar palonosetron (0.5 microg) also did not change the paw withdrawal threshold.
CONCLUSIONS
Intrathecal and intraplantar palonosetron (0.5 microg) had no effect on modulating the mechanical hypersensitivity in the incisional pain model of rats.

Keyword

5-HT3 receptor; nociceptive pain; pain threshold; palonosetron; Sprague-Dawley rats

MeSH Terms

Anesthesia
Animals
Catheters
Cisterna Magna
Hyperalgesia
Hypersensitivity
Isoquinolines
Methyl Ethers
Muscle, Skeletal
Nociceptive Pain
Pain Threshold
Pain, Postoperative
Quinuclidines
Rats
Rats, Sprague-Dawley
Receptors, Serotonin, 5-HT3
Serotonin
Isoquinolines
Methyl Ethers
Quinuclidines
Receptors, Serotonin, 5-HT3
Serotonin
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