Intest Res.  2010 Jun;8(1):9-17. 10.5217/ir.2010.8.1.9.

Pathogenesis of Inflammatory Bowel Diseases

Affiliations
  • 1Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. mamoru.gast@tmd.ac.jp

Abstract

Our understanding of IBD pathogenesis has been increasing rapidly. The genetically determined interplay between the commensal microbiota, intestinal epithelial cells, and the immune system has been appreciated deeply. The interplay is also considered to be modified by specific environmental factors. This review examines the recent findings from the animal and human studies on IBD pathogenesis and the implications for future effective therapies.

Keyword

Pathogenesis; Inflammatory Bowel Diseases

MeSH Terms

Animals
Epithelial Cells
Humans
Immune System
Inflammatory Bowel Diseases
Metagenome
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