Cancer Res Treat.  2012 Sep;44(3):173-178.

Metachronous Double Primary Cancer after Diagnosis of Gastric Cancer

• Kim JY
• Jang WY
• Heo MH
• Lee KK
• Do YR
• Park KU
• Song HS
• Kim YN

Abstract

PURPOSE
The pattern of double primary cancers after treatment for gastric cancer is important for a patient's survival.
MATERIALS AND METHODS
We analyzed the clinicopathologic data of 214 gastric cancer patients from October 1996 to November 2007 with regard to metachronous second primary cancers.
RESULTS
Out of 5,778 patients with gastric cancer, metachronous second primary cancers occurred in 214 patients. The median age was 61.8 years, the number of male and female patients was 140 (65.4%), 74 (34.6%), respectively. The median time to the occurrence of second cancers after diagnosis of the first was 39.2 months (standard deviation, 31.2 months). The most common cancer was colorectal cancer, which occurred in 44 patients (20.6%), and lung cancer in 33 patients (15.4%), hepatocellular carcinoma in 26 patients (12.1%), ovarian cancer in 15 patients (7.0%), cervical cancer in 12 patients (7.0%), breast cancer in 11 patients (5.1%), and esophageal cancer in 11 patients (5.1%). The observed/expected (O/E) ratio showed a significant increase in colorectal (1.25), male biliary (1.60), ovarian (8.72), and cervical cancer (3.33) with primary gastric cancer. After five years from diagnosis of gastric cancer, secondary cancer occurred in 50 patients (23.4%), and breast cancer, prostate cancer, laryngeal cancer, lung cancer, and hepatocellular carcinoma were the most frequent.
CONCLUSION
The O/E ratio showed a significant increase in colorectal, male biliary, ovarian, and cervical cancer with primary gastric cancer, and second primary cancer as the main cause of death for these patients. A follow-up examination for metachronous double primary cancer is needed in order to improve the survival time in patients with gastric cancer.

Keyword

Stomach neoplasm; Second primary neoplasms; Diagnosis

MeSH Terms

Breast Neoplasms
Carcinoma, Hepatocellular
Cause of Death
Colorectal Neoplasms
Esophageal Neoplasms
Female
Follow-Up Studies
Humans
Laryngeal Neoplasms
Lung Neoplasms
Male
Neoplasms, Second Primary
Ovarian Neoplasms
Prostatic Neoplasms
Stomach Neoplasms
Uterine Cervical Neoplasms

Figure

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  Fig. 1 Four-year survival rate for gastric cancer patients without double primary cancer.

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