Tuberc Respir Dis.  2006 Sep;61(3):233-238. 10.4046/trd.2006.61.3.233.

Predictors on In-hospital Mortality Following In-hospital Diagnosis of Tuberculosis

• Shin SR
• Kim CH
• Kim SE
• Park YB
• Lee JY
• Mo EK
• Kim CH
• Eom KS
• Jang SH
• Kim DG
• Lee MG
• Jung KS

• KMID: 1970262
• DOI: http://doi.org/10.4046/trd.2006.61.3.233

Abstract

STUDY OBJECTIVES: To determine the factors associated with mortality after an in-hospital diagnosis of tuberculosis in a region with low levels of HIV coinfection.
METHODS
From January 2003 to December 2004, all subjects who were > 15 years of age and had received a diagnosis of tuberculosis were registered. The clinical, radiological and laboratory aspects of the patients who died (n=27) were compared with those of an age and gender matched control population(n=54). Logistic regression analyses were carried out, which included age, gender, hospital admission source, initial site of admission, dyspnea, general weakness and initial laboratory data.
RESULTS
The mean age of the patients was 60 +/- 16 years and male patients outnumbered female patients. Univariate analysis identified hemoglobin, blood urea nitrogen, albumin, cholesterol, aspartate aminotransferase (AST), C-reactive protein and the risk factors for tuberculosis to be significantly associated with mortality. Among the characteristics of disease presentation and treatment, emergency department admission, intensive care unit, disease severity, general weakness and dyspnea at the time of admission were associated with mortality. Multiple regression analysis revealed the initial management in the intensive care unit and lower serum albumin to be independently associated with mortality.
CONCLUSION
The markers of disease chronicity and severity appear to be associated with in-hospital mortality. Identifying potentially reversible factors such as malnutrition and respiratory failure suggests specific intervention that might lead to an improvement in the patients' outcomes.

Keyword

Mycobacterium tuberculosis; Mortality; Tuberculosis

MeSH Terms

Aspartate Aminotransferases
Blood Urea Nitrogen
C-Reactive Protein
Cholesterol
Coinfection
Diagnosis*
Dyspnea
Emergency Treatment
Female
HIV
Hospital Mortality*
Humans
Intensive Care Units
Logistic Models
Male
Malnutrition
Mortality
Mycobacterium tuberculosis
Respiratory Insufficiency
Risk Factors
Serum Albumin
Tuberculosis*
Aspartate Aminotransferases
C-Reactive Protein
Cholesterol
Serum Albumin

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