Ewha Med J.  1996 Dec;19(4):459-462. 10.12771/emj.1996.19.4.459.

Amniotic Fluid Alpha-fetoprotein Levels in Midtrimester Pregnancies

Affiliations
  • 1Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Korea.

Abstract


OBJECTIVE
The purpose of this study is to establish the normal levels of alpha-fetoprotein in amniotic fluid between 15 and 22 weeks of gestation. METHOD: Amniotic fluid Alpha-fetoprotein(AFAFP)levels were measured by enzyme-immunoassy in pregnant women between 15 and 22 weeks of gestation for variety of indication of amniocentesis from October, 1994 to July, 1996 at Mokdong Hospital Ewha Womans University. The study group was selected from normal karyotype at prenatal genetic diagnosis and no congenital anomaly of fetus.
RESULTS
The normal level of AFAFP was the highest at 16weeks and then it declined gradually as gestational weeks increased. The mean+/-SD levels of AFAFP from 15 to 22weeks were 16.9+/-5.7, 20.4+/-9.8, 13.8+/-6.8, 10.9+/-3.0, 8.1+/-2.3, 6.9+/-3.9, 5.6+/-1.6, 4.7+/-0.6microg/ml respectively, the median levels of AFAFP from 15 to 22weeks were 14.7, 16.2, 12.3, 11.0, 7.8, 5.5, 5.3, 4.8microg/ml, respectively.
CONCLUSION
We consider that this preliminary data normal AFAFP levels by each gestation weeks can be used as reference value for screening of anomalies or genetic disorder.

Keyword

Amniotic fluid; Alpha-fetoprotein(AFP); Midtrimester; Pregnauay

MeSH Terms

alpha-Fetoproteins*
Amniocentesis
Amniotic Fluid*
Diagnosis
Female
Fetus
Humans
Karyotype
Mass Screening
Pregnancy
Pregnancy Trimester, Second*
Pregnancy*
Pregnant Women
Reference Values
alpha-Fetoproteins
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