J Korean Med Assoc.  2015 Feb;58(2):147-153. 10.5124/jkma.2015.58.2.147.

Drug therapy for the common cold

Affiliations
  • 1Department of Family Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. pclove@hallym.or.kr

Abstract

The common cold is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Drug therapies for the common cold are normally aimed at relieving the symptoms of the illness. Over-the-counter cough and cold medications should not be used in children younger than four years old because of potential harms and lack of benefit. Antibiotics, antitussives, anti-histamines, and inhaled corticosteroids are not effective in children. Products that may improve symptoms in children include expectorants, mucolytics, honey, vitamin C, zinc lozenges, geranium extract, and nasal saline irrigation. In adults, antihistamines, intranasal corticosteroids, codeine, intranasal ipratopium, and antibiotics are not effective. Decongestants, antihistamine/decongestant combi-nations, expectorants, and mucolytics may improve cold symptoms in adults. Nonsteroidal anti-inflammatory drugs and acetaminophen reduce pain secondary to upper respiratory tract infection in adults. Among complementary and alternative medicinetherapeutics, products containing vitamin C, zinc, or garlic may improve cold symptoms in adults. Prophylactic use of probiotics may decrease the frequency of colds in adults and children.

Keyword

Common cold; Anti-inflammatory agents, non-steroidal; Complementary therapies; Nonprescription drugs; Antitussive agents

MeSH Terms

Acetaminophen
Adrenal Cortex Hormones
Adult
Anti-Bacterial Agents
Anti-Inflammatory Agents, Non-Steroidal
Antitussive Agents
Ascorbic Acid
Child
Codeine
Common Cold*
Complementary Therapies
Cough
Drug Therapy*
Expectorants
Garlic
Geranium
Histamine Antagonists
Honey
Humans
Larynx
Nasal Decongestants
Nonprescription Drugs
Nose
Pharynx
Probiotics
Respiratory System
Respiratory Tract Infections
Zinc
Acetaminophen
Adrenal Cortex Hormones
Anti-Bacterial Agents
Anti-Inflammatory Agents, Non-Steroidal
Antitussive Agents
Ascorbic Acid
Codeine
Expectorants
Histamine Antagonists
Nasal Decongestants
Nonprescription Drugs
Zinc

Reference

1. Allan GM, Arroll B. Prevention and treatment of the common cold: making sense of the evidence. CMAJ. 2014; 186:190–199.
Article
2. Kim SY. Evidence-based upper respiratory infection prescription. J Korean Med Assoc. 2003; 46:851–857.
Article
3. Robohm C, Ruff C. Diagnosis and treatment of the common cold in pediatric patients. JAAPA. 2012; 25:43–47.
Article
4. Fashner J, Ericson K, Werner S. Treatment of the common cold in children and adults. Am Fam Physician. 2012; 86:153–159.
5. US Food and Drug Administration. Use of over-the-counter (OTC) cough and cold products in infants and children: full version [Internet]. Silver Spring: US Food and Drug Admini-stration;cited 2015 Jan 5. Available from: http://www.fda.gov/drugs/drugsafety/drugsafetypodcasts/ucm077935.htm.
6. Shehab N, Schaefer MK, Kegler SR, Budnitz DS. Adverse events from cough and cold medications after a market withdrawal of products labeled for infants. Pediatrics. 2010; 126:1100–1107.
Article
7. US Food and Drug Administration. FDA statement following CHPA's announcement on nonprescription over-the-counter cough and cold medicines in children [Internet]. Silver Spring: US Food and Drug Administration;cited 2015 Jan 5. Avail-able from: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2008/ucm116964.htm.
8. Kenealy T, Arroll B. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev. 2013; 6:CD000247.
Article
9. Smith SM, Schroeder K, Fahey T. Over-the-counter (OTC) medi-cations for acute cough in children and adults in community settings. Cochrane Database Syst Rev. 2014; 11:CD001831.
Article
10. De Sutter AI, van Driel ML, Kumar AA, Lesslar O, Skrt A. Oral antihistamine-decongestant-analgesic combinations for the common cold. Cochrane Database Syst Rev. 2012; 2:CD004976.
Article
11. Chalumeau M, Duijvestijn YC. Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paedia-tric patients without chronic broncho-pulmonary disease. Cochrane Database Syst Rev. 2013; 5:CD003124.
Article
12. Hayward G, Thompson MJ, Perera R, Del Mar CB, Glasziou PP, Heneghan CJ. Corticosteroids for the common cold. Cochrane Database Syst Rev. 2012; 8:CD008116.
Article
13. Panickar J, Lakhanpaul M, Lambert PC, Kenia P, Stephenson T, Smyth A, Grigg J. Oral prednisolone for preschool children with acute virus-induced wheezing. N Engl J Med. 2009; 360:329–338.
Article
14. McKean M, Ducharme F. Inhaled steroids for episodic viral wheeze of childhood. Cochrane Database Syst Rev. 2000; (2):CD001107.
Article
15. Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE. Honey for acute cough in children. Cochrane Database Syst Rev. 2014; 12:CD007094.
Article
16. Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev. 2013; 6:CD001364.
Article
17. Science M, Johnstone J, Roth DE, Guyatt G, Loeb M. Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. CMAJ. 2012; 184:E551–E561.
Article
18. Lissiman E, Bhasale AL, Cohen M. Garlic for the common cold. Cochrane Database Syst Rev. 2014; 11:CD006206.
Article
19. Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013; 1:CD000980.
20. Guppy MP, Mickan SM, Del Mar CB. "Drink plenty of fluids": a systematic review of evidence for this recommendation in acute respiratory infections. BMJ. 2004; 328:499–500.
Article
21. Slapak I, Skoupa J, Strnad P, Hornik P. Efficacy of isotonic nasal wash (seawater) in the treatment and prevention of rhinitis in children. Arch Otolaryngol Head Neck Surg. 2008; 134:67–74.
Article
22. Timmer A, Gunther J, Motschall E, Rucker G, Antes G, Kern WV. Pelargonium sidoides extract for treating acute respiratory tract infections. Cochrane Database Syst Rev. 2013; 10:CD006323.
Article
23. Cohen HA, Varsano I, Kahan E, Sarrell EM, Uziel Y. Effectiveness of an herbal preparation containing echinacea, propolis, and vitamin C in preventing respiratory tract infections in children: a randomized, double-blind, placebo-controlled, multicenter study. Arch Pediatr Adolesc Med. 2004; 158:217–221.
Article
24. Paul IM, Beiler JS, King TS, Clapp ER, Vallati J, Berlin CM Jr. Vapor rub, petrolatum, and no treatment for children with nocturnal cough and cold symptoms. Pediatrics. 2010; 126:1092–1099.
Article
25. Taverner D, Latte J. Nasal decongestants for the common cold. Cochrane Database Syst Rev. 2007; (1):CD001953.
Article
26. Bolser DC. Cough suppressant and pharmacologic protussive therapy: ACCP evidence-based clinical practice guidelines. Chest. 2006; 129:238S–249S.
27. Kim SY, Chang YJ, Cho HM, Hwang YW, Moon YS. Non-steroidal anti-inflammatory drugs for the common cold. Cochrane Database Syst Rev. 2013; 6:CD006362.
Article
28. Li S, Yue J, Dong BR, Yang M, Lin X, Wu T. Acetaminophen (paracetamol) for the common cold in adults. Cochrane Database Syst Rev. 2013; 7:CD008800.
Article
29. Choi IK, Lee HK, Ji YJ, Hwang IH, Kim SY. A comparison of the efficacy and safety of non-steroidal anti-inflammatory drugs versus acetaminophen in symptom relief for the common cold: a meta-analysis of randomized controlled trial studies. Korean J Fam Med. 2013; 34:241–249.
Article
30. AlBalawi ZH, Othman SS, Alfaleh K. Intranasal ipratropium bromide for the common cold. Cochrane Database Syst Rev. 2013; 6:CD008231.
Article
31. Hemila H. Vitamin C and common cold-induced asthma: a systematic review and statistical analysis. Allergy Asthma Clin Immunol. 2013; 9:46.
32. Lee HK, Hwang IH, Kim SY, Pyo SY. The effect of exercise on prevention of the common cold: a meta-analysis of randomized controlled trial studies. Korean J Fam Med. 2014; 35:119–126.
Article
33. Kang EJ, Kim SY, Hwang IH, Ji YJ. The effect of probiotics on prevention of common cold: a meta-analysis of randomized con-trolled trial studies. Korean J Fam Med. 2013; 34:2–10.
Article
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