J Korean Med Assoc.  2004 Nov;47(11):1048-1055. 10.5124/jkma.2004.47.11.1048.

Brucellosis

Affiliations
  • 1Department of Preventive Medicine, College of Medicine, Dongguk University, Korea.

Abstract

Brucellosis is a systemic bacterial disease with an acute or insidious onset, characterized by continued, intermittent, or irregular fever of variable duration, headache, weakness, sweating, chills, arthralgia, depression, weight loss, and generalized aching. It is predominantly an occupational disease among those working with infected animals or their tissues, especially farm workers, veterinarians, and abattoir workers. Brucellosis has been an emerging disease since the discovery of Brucella melitensis by Bruce in 1887. Worldwide, brucellosis remains a major source of disease in humans and domesticated animals. Although the reported incidence and prevalence of the disease vary widely from country to country, bovine brucellosis caused mainly by B. abortus is still the most widespread form, also occurring in Korea. The vaccination for Brucella was first done on cows in 1998. After inoculation, Brucella developed in a group of cows. And then the first human case occurred in 2002, followed by 16 cases in 2003 by B. abortus. Prevention of brucellosis in humans still depends on the eradication or control of the disease in animal hosts, hygienic precautions to limit the exposure to infection through occupational activities, and effective heating of dairy products or other potentially contaminated foods. Physicians and veterinarians should be concerned about specific environments and clinical patterns of brucellosis. They should make efforts to recognize, evaluate, and control brucellosis.

Keyword

Brucellosis; Zoonosis; Occupation; Veterinarians

MeSH Terms

Abattoirs
Animals
Animals, Domestic
Arthralgia
Brucella
Brucella melitensis
Brucellosis*
Brucellosis, Bovine
Cattle
Chills
Dairy Products
Depression
Fever
Headache
Heating
Hot Temperature
Humans
Incidence
Korea
Occupational Diseases
Occupations
Prevalence
Sweat
Sweating
Vaccination
Veterinarians
Weight Loss

Reference

2. Corbel MJ. Brucellosis-an overview. Emerg Infect Dis. 1997. 3:213–221.
3. Bravo MJ, de Dios Colmenero J, Alonso A, Caballero A. Polymorphisms of the interferon gamma and interleukin 10 genes in human brucellosis. Eur J Immunogenet. 2003. 30:433–435.
Article
4. Clavijo E, Diaz R, Anguita A, Garcia A, Pinedo A, Smits HL. Comparison of a dipstick assay for detection of Brucella-specific immunoglobulin m antibodies with other tests for serodiagnosis of human brucellosis. Clin Diagn Lab Immunol. 2003. 10:612–615.
Article
5. Doganay M, Aygen B. Human brucellosis: an overview. Int J Infect Dis. 2003. 7:173–178.
Article
6. Nimri LF. Diagnosis of recent and relapsed cases of human brucellosis by PCR assay. BMC Infect Dis. 2003. 3:5.
Article
7. Sauret JM, Vilissova N. Human brucellosis. J Am Board Fam Pract. 2002. 15:401–416.
13. Malik GM. A clinical study of brucellosis in adults in the Asian region of southern Saudi Arabia. Am J Trop Med Hyg. 1997. 56:375–377.
Article
14. CDC . Brucellosis ; Reported cases, by year, United States, 1971-2001. MMWR. 2001. 50:31.
21. Brucellosis(Brucella melitensis, abortus, suis, and canis). CDC. cited 2004 April 21. Available from: http://www.cdc.gov/ncidod/dbmd/diseaseinfo/brucellosis_t.htm.
23. Hoover DL, Friedlander AM. Brucellosis. cited 2004 April 21. Available from: http://www.vnh.org/MedAspChemBioWar/chapters/chapter_25.htm.
25. Morata P, Queipo-Ortuno MI, Reguera JM, Garcia-Ordonez MA, Cardenas A, Colmenero JD. Development and evaluation of a PCR-enzyme-linked immunosorbent assay for diagnosis of human brucellosis. J Clin Microbiol. 2003. 41:144–148.
Article
26. Araj GF, Lulu AR, Mustafa MY, Khateeb MI. Evaluation of ELISA in the diagnosis of acute and chronic brucellosis in human beings. J Hyg (Lond). 1986. 97:457–469.
Article
Full Text Links
  • JKMA
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr