J Korean Ophthalmol Soc.  1988 Aug;29(4):511-515.

The Anticollagenase Effect of Serum in Alkali-burned Cornea in Rabbit

• Park DH
• Yoon BJ

Abstract

The possible role of collagenase in the development of corneal ulcers has been intensively studied and collagenase inhibitors have been successfully used to control some corneal ulcers. They are cysteine, EDTA, proteoglycan, serum, and medroxyprogesteron, However, most of them are limited in clinical use because of their toxicity and instability except serum, which is not toxic to the host. We carried out an experiment with serum upon alkali-burned rabbit cornea. Serum has potent anticollagenase effect, and prevents corneal ulceration.

MeSH Terms

Collagenases
Cornea*
Corneal Ulcer
Cysteine
Edetic Acid
Matrix Metalloproteinase Inhibitors
Proteoglycans
Ulcer
Collagenases
Cysteine
Edetic Acid
Matrix Metalloproteinase Inhibitors
Proteoglycans