J Korean Vasc Surg Soc.  1998 Nov;14(2):287-294.

The Sclerosing Effects and Histopathologic Changes of Sclerosants for Rabbit Ear and Skin

Affiliations
  • 1Department of Surgery, Kyunghee University College of Medicine, Korea.

Abstract

To evaluate the sclerotic effects and skin damage of varicose sclerosing agents such as polidocanol, sodium tetradecyl sulfate, hypertonic saline, ethanolamine oleate, these agents were injected into rabbit ear vein and subcutaneous tissue, and the tissue specimens were obtained after 3 hours and 24 hours. The results were as follows. 1) The detergent sclerosing agents (polidocanol, sodium tetradecyl sulfate and ethanolamine sulfate) have strong sclerosing effect and showed the difference in effect according to their concentration, and the skin change was more severe than osmotic agent. 2) The sclerosing effect of osmotic agent (hypertonic saline) was equal to or somewhat less than that of detergent sclerosing agents, but the skin change was minimal. Therefore in the sclerotherapy of early phase varicose vein and telangiectasia, use of osmotic agent (23.4% hypertonic saline) or diluted detergent sclerosing agents (0.75% polidocanol, 0.25% sodium tetradecyl sulfate and 1.5% ethanolamine oleate) might be safe, but in case of more advanced varicose vein, the detergent sclerosing agents (1% polidocanol, 0.5% sodium tetradecyl sulfate and 3% ethanolamine oleate), which have strong sclerosing effect, might be useful.

Keyword

Varicose vein; Sclerosing agent

MeSH Terms

Detergents
Ear*
Ethanolamine
Oleic Acid
Sclerosing Solutions*
Sclerotherapy
Skin*
Sodium Tetradecyl Sulfate
Subcutaneous Tissue
Telangiectasis
Varicose Veins
Veins
Detergents
Ethanolamine
Oleic Acid
Sclerosing Solutions
Sodium Tetradecyl Sulfate
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