Korean J Gastrointest Endosc.  2011 Feb;42(2):113-117.

Early Adenocarcinoma Arising from Traditional Serrated Adenoma in the Colon

  • 1Department of Internal Medicine, Gang Dong Kyung Hee University Hospital, Kyunghee University College of Medicine, Seoul, Korea. dramc@hanmail.net


A serrated adenoma is a precursor lesion for some cases of microsatellite unstable colorectal carcinoma (CRC). The serrated neoplasia pathway has been associated with carcinogenesis of serrated adenoma, which is different from the traditional adenoma-carcinoma sequence. The serrated neoplasia pathway accounts for 10~15% of CRCs, and these tumors typically demonstrate microsatellite instability. Cases of a CRC arising from a serrated adenoma have been rarely identified with the recent recognition of the serrated neoplasia pathway. However, these cases are not frequently reported in Korea, because this concept has only been recently emphasized. We report a case of an early adenocarcinoma arising from a traditional serrated adenoma of the colon, which was diagnosed and treated by a colonoscopic polypectomy.


Traditional serrated adenoma; Colon; Adenocarcinoma
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