Korean J Anesthesiol.  1997 Apr;32(4):510-517. 10.4097/kjae.1997.32.4.510.

Interaction of Magnesium Sulfate with Mivacurium-induced Neuromuscular Block in Rabbits

• Kim KS
• Won SK
• Lee JK

• KMID: 1934607
• DOI: http://doi.org/10.4097/kjae.1997.32.4.510

Abstract

BACKGROUND
Magnesium sulfate(MgSO4) has long been used in the treatment of pre-eclampsia and hypertension. Mivacurium was found to undergo hydrolysis by plasma cholinesterase at 70-88% of the rate of succinylcholine. This study has been conducted to evaluate the time course of mivacurium-induced neuromuscular block according to the pretreatment doses of MgSO4 in rabbits.
METHODS
This study was done using a common peroneal nerve-anterior tibialis muscle preparation in sixty adult rabbits. The onset and recovery times of mivacurium(0.16 mg/kg) were evaluated after the infusion of a placebo in group 1, MgSO4 30 mg/kg in group 2, MgSO4 50 mg/kg in group 3 and MgSO4 70 mg/kg in group 4, respectively(n=15 each).
RESULTS
The mean serum concentration of magnesium was 2.4 mEq/L in group 1, 3.3 mEq/L in group 2, 4.3 mEq/L in group 3 and 5.5 mEq/L in group 4, respectively. The mean time from injection of mivacurium to 95% recovery of twitch amplitude was 32.7 min. in group 1, 32.9 min. in group 2, 30.4 min. in group 3 and 33.0 min. in group 4, respectively.
CONCLUSIONS
The results of the present study suggested that the neuromuscular blocking actions of mivacurium are not affected according to the pretreatment doses of MgSO4.

Keyword

Neuromuscular relaxants; Mivacurium; Ions; Magnesium

MeSH Terms

Adult
Cholinesterases
Humans
Hydrolysis
Hypertension
Ions
Magnesium Sulfate*
Magnesium*
Neuromuscular Blockade*
Plasma
Pre-Eclampsia
Rabbits*
Succinylcholine
Cholinesterases
Ions
Magnesium
Magnesium Sulfate
Succinylcholine