Korean J Clin Pathol.  2000 Feb;20(1):24-29.

Clinical Usefulness of the CK-MB Activity and Cardiac Troponin T as Markers for Detection of Acute Myocardial Infarction

• Oh GY
• Hong KS

Abstract

BACKGROUND: The goal of this study is to assess the clinical utility of cardiac troponin T(cTnT) and creatine kinase MB(CK-MB) activity and to determine optimum decision thresholds by using receiver operating characteristic(ROC) curve for cTnT and CK-MB. METHOD: We evaluated serum cTnT(Elecsys 2010, Boeringer Manheim, Germany) and CK-MB activity(XRC, Johnson & Johnson Clinical Diagnostics, USA) in 15 cases(124 samples) of acute myocardial infarction(AMI) and 64 cases(98 samples) of non-AMI patients from April 1998 to October 1998.
RESULTS
CK-MB activity [cut-off value 16 U/L, relative index(CK-MB 100/total CK) 4-25%)] and cTnT(cut-off value 0.1 ng/mL) were detected in serum within 3 hours after onset of chest pain and cTnT was persistent to longer times than CK-MB activity. Sensitivity of cTnT(69.6%) is not statistically different from CK-MB activity(72.9%) within 24 hours of chest pain but more sensitive after 24 hours of symptom. Specificity(87.9%) and negative predictive value(91.2%) of cTnT were superior to that of CK-MB activity within 24 hours of chest pain. ROC curve analysis demonstrated the following decision cutoff, sensitivity, specificity: cTnT 0.13 ng/mL, 76.7%, 100%; CK-MB activity 14 U/L, 84.7% and 71.0%.
CONCLUSION
Measurement of cTnT was useful for late admitted AMI and together with CK-MB could improve the detection of myocardial infarction.

Keyword

Cardiac troponin T; Acute myocardial infarction; Creatine kinase MB activity

MeSH Terms

Chest Pain
Creatine Kinase
Humans
Myocardial Infarction*
ROC Curve
Sensitivity and Specificity
Troponin T*
Troponin*
Creatine Kinase
Troponin
Troponin T