Korean J Dermatol.
1994 Oct;32(5):832-837.
Effects of 8 - Methoxypsoralen ( 8 - MOP ) on the Proliferation and Melanization of Cultured Normal Human Melanocytes without UVA
Abstract
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BACKGROUND: Psoralen has been used in the treatment of certain hypojigmentary disorders with UVA or solar irradiation. However trecent report proposed the actions of psiralens are direct and do not require the presence of ultraviolet light. The report also suggested that tze specific receptors other than DNA would be present.
OBJECTIVE
This study was done ta identify the effects of 8-methoryporalen(8-MOP) on the proliferation and melanization of cultured normal human melanocytes without UVA.
METHODS
Melanocytes were cultured in melanocyte culture medium neluding 16% or 5% FBS. We added 8-MOP by their concentrations from 10 M to 10 M. After 8 hours treatment, we investigated the melanocytes proliferation and Lhe melanin contents.
RESULTS
We could not detecet any significant differences of melanoytes proliferation and melanin contents between the control end experimental groups.
CONCLUSION
There were no effect on the proliferation and the milanization of cultured normal human melanocytes with 8-MOP only.
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