Korean J Gastrointest Endosc.  2005 Dec;31(6):409-413.

Synchronous Double Primary Cancer: Gastric Hepatoid Adenocarcinoma and Rectal Adenocarcinoma

  • 1Department of Internal Medicine, Pusan National University College of Medicine, Busan, Korea. popeyes0212@hanmail.net


Hepatoid adenocarcinoma (HAC) of the stomach is a rare neoplasm consisting of both adenocarcinomatous and hepatocellular carcinoma (HCC)-like foci; the latter of which showed the full spectrum of morphological and functional features of HCC. Numerous cases of HAC have been reported in a variety of primary organs, the stomach is one of the most common sites. HAC is associated with an increased serum alpha-fetoprotein (AFP) level and a strong tendency for lymphatic and venous invasion. Because of early hepatic metastasis, prognosis seems less favorable than more common types of adenocarcinoma. Here, we report a case of synchronous double primary cancer, consisting of hepatoid adenocarcinoma of the stomach and adenocarcinoma of the rectum.


Hepatoid adenocarcinoma; Double primary cancer; Rectal adenocarcinoma
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