Korean J Gastrointest Endosc.  2006 Mar;32(3):194-199.

A Case of Gastric CD56+ Extranodal NK/T-cell Lymphoma, Nasal Type

Affiliations
  • 1Department of Internal Medicine, Ewha Medical Research Institute, Ewha Womans University College of Medicine, Seoul, Korea. shimkn@ewha.ac.kr
  • 2Department of Pathology, Ewha Medical Research Institute, Ewha Womans University College of Medicine, Seoul, Korea.

Abstract

A NK/T cell lymphoma is highly aggressive lymphoma of a putative NK-cell origin with a predominant extranodal presentation and a rapidly fatal course. CD56 has been reported to be the most reliable marker for a NK/T cell lymphoma. A NK/T cell lymphoma is strongly associated with the Epstein-Barr virus. We report a case of an aggressive NK/T cell lymphoma presenting as a gastric ulcer. A 52-year-old female patient presented with hematochezia and fever. The endoscopic finding showed a gastric ulcer with a recent bleeding stigma. Histologically, the gastric biopsy showed a diffuse infiltration of small or medium sized lymphoma cells with an angiocentric growth pattern and necrosis. The lymphoma cells were CD56+, CD3+, CD20-, which are consistent with a NK/T cell lymphoma. Unfortunately, the patient was discharged without treatment. We report this case with a review of the relevant literature.

Keyword

NK/T cell lymphoma; Stomach
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