Korean J Gastrointest Endosc.  1995 Mar;15(1):12-25.

Comparison of Hemostatic Effect of Endoscopic Injection with Fibrin Glue (FG) and Hypertonic Saline - epinephrine (HSE) for Peptic Ulcer Bleeding: A prospective randomized trial

• Moon YM
• Kang JK
• Park IS
• Chon CY
• Chung JB
• Han KH
• Kim WH
• Song SY
• Won WH

Abstract

Endoscopic injection therapy using various different agents(ethanol, polidocanol, epinephrine with and without hypertonic saline, etc.) is considered as the least expensive and effective technique to obtain hemostasis in peptic ulcer bleeding, however most of these agents induce tissue necrosis or degeneration. Theoretically the injection of fibrin glue in peptic ulcer bleeding may be safer than that of other agents, however, to date, there have been no data from randomized clinical trials on the comparison of the efficacies between these agents. To compare the hemostatic efficacy between FG[Beriplast P, Behring, Germany] and HSE[3% saline and epinephrine(1: 10,000)], we conducted a prospective, randomized, clinical trial among one hundred twenty-seven patients with peptic ulcer bleeding from March, 1992 to December, 1993 and in whom a visible vessel or active bleeding was identified.

Keyword

Fibrin glue; Hypertonic saline - epinephrine; Endoscopic injection therapy; Peptic ulcer bleeding

MeSH Terms

Epinephrine*
Fibrin Tissue Adhesive*
Fibrin*
Hemorrhage*
Hemostasis
Humans
Necrosis
Peptic Ulcer*
Prospective Studies*
Epinephrine
Fibrin
Fibrin Tissue Adhesive