Korean J Obstet Gynecol.  1997 Feb;40(2):281-285.

Tumor Necrosis Factor-alpha in Midtrimester Amniotic Fluid is Associated with Pregnancy Outcome?

• Choi HM
• Cho JS
• Kim KS
• Yang YH
• Park YW
• Kim JW

Abstract

OBJECTIVE
Our purpose is to investigate if tumor necrosis factor-alpha(TNF-alpha) levels in midtrimester correlate with pregnancies complicated by preterm labor, preeclamsia, and intrauterine growth retardation(IUGR). STUDY DESIGN: A case control study design was used to compare midtrimester amniotic fluid TNF-alpha levels from women with normal pregnancy outcome(n=54) and pregnancies complicated by preterm labor(n=10), preeclampsia(n=8), and IUGR(n=4). RESULT: TNF-alpha levels in midtrimester amniotic fluid in women with normal pregnancy ourcome were 8.8+/-4.0pg/ml. Also, TNF-alpha levels in women with preterm labor, preeclamsia, and IUGR were 9.7+/-6.0pg/ml, 6.0+/-4.1pg/ml, 7.5+/-2.6pg/ml respectively.
CONCLUSION
TNF-alpha levels in midtrimester amniotic fluid do not correlate with pregnancies complicated by preterm labor, preeclamsia, and IUGR different from the third trimester(p=0.06).

Keyword

TNF-alpha; Amniotic fluid; Midtrimester; Pregnancy outcome

MeSH Terms

Amniotic Fluid*
Case-Control Studies
Female
Fetal Growth Retardation
Humans
Necrosis
Obstetric Labor, Premature
Pregnancy
Pregnancy Outcome*
Pregnancy Trimester, Second*
Pregnancy*
Tumor Necrosis Factor-alpha*
Tumor Necrosis Factor-alpha